Thirty-five kinds of herbal drugs, believed to be active for treatment of tumors, were selected as the experimental materials for observing their effects on TPA-induced adherence of HL-60 cell and activity of protein kinase C. They were extracted
with
ethyl ether(E) and ethyl acetate(EA), methanol(M) in sequence. Among the extracts, Sophorae Flos(EA), Paeoniae Radix (EA), Equisetum hiemale(EA), phellodendri cortex(E, EA), Mori Cortex radicis(EA), Ferula assafoetida(E, EA), Sophora
subprostrata(EA, M)
and Cnidium monnieri(E) inhibited the TPA-induced adherence ofHL-60 cell more than 50% and Sophorae Flos(E, EA, M), Paeoniae Radix(E, EA, M), Equisetum hiemale(E), Phellodenri Cortex(E, M), Mori Cortex radicis(M), Ferula assafoetida(M), Sophora
subprostrata(EA, M), Cnidium monnieri(M) and Artemisia argyi(M) showed inhibiting effects on the activity of protein kinase C more than 50%.
The extracts showing good inhibiting effects on the adherence and enzyme activity were Sophorae Flos(EA), Paeoniae Radix(EA), Phellodendri Cortex(E), Sophora subsprostrata(EA) and Equisetum hiemale(EA).
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